(AMLX) Amylyx Pharmaceuticals - Overview

Sector: Healthcare | Industry: Drug Manufacturers - Specialty & Generic | Exchange: NASDAQ (USA) | Market Cap: 1.510m USD | Total Return: 192.9% in 12m

Neurodegenerative Treatments, Endocrine Therapeutics, Receptor Antagonists
Total Rating 39
Safety 59
Buy Signal -0.31
Market Cap: 1.51B
Avg Turnover: 14.4M
Risk 3d forecast
Volatility65.0%
VaR 5th Pctl10.4%
VaR vs Median-2.69%
Reward TTM
Sharpe Ratio1.87
Rel. Str. IBD86
Rel. Str. Peer Group77.3
Character TTM
Beta0.886
Beta Downside0.044
Hurst Exponent0.641
Drawdowns 3y
Max DD93.83%
CAGR/Max DD-0.18
CAGR/Mean DD-0.28
EPS (Earnings per Share) EPS (Earnings per Share) of AMLX over the last years for every Quarter: "2021-03": null, "2021-06": null, "2021-09": -3.81, "2021-12": -4.15, "2022-03": -0.93, "2022-06": -0.93, "2022-09": -0.92, "2022-12": -0.65, "2023-03": 0.02, "2023-06": 0.31, "2023-09": 0.3, "2023-12": 0.07, "2024-03": -0.12, "2024-06": -0.62, "2024-09": -1.07, "2024-12": -0.55, "2025-03": -0.42, "2025-06": -0.46, "2025-09": -0.37, "2025-12": -0.3, "2026-03": -0.37,
Last SUE: -0.12
Qual. Beats: 0
Revenue Revenue of AMLX over the last years for every Quarter: 2021-03: 0, 2021-06: 0, 2021-09: 0.285, 2021-12: 0, 2022-03: 0, 2022-06: 0, 2022-09: 0.345, 2022-12: 21.885, 2023-03: 71.428, 2023-06: 98.216, 2023-09: 102.693, 2023-12: 108.449, 2024-03: 88.643, 2024-06: -1.023, 2024-09: 0.416, 2024-12: -0.665, 2025-03: 0, 2025-06: 0, 2025-09: 0, 2025-12: 0, 2026-03: 0,
Last SUE: 0.00
Qual. Beats: 0

Warnings

Share dilution 29.1% YoY

Altman Z'' -15.00 < 1.0 - financial distress zone

Volatile Below Avwap Earnings

Tailwinds

No distinct edge detected

Description: AMLX Amylyx Pharmaceuticals

Amylyx Pharmaceuticals, Inc. (AMLX) is a Cambridge-based clinical-stage biotechnology firm focused on developing therapies for neurodegenerative and endocrine disorders. The company’s pipeline is headlined by Avexitide, a GLP-1 receptor antagonist currently in Phase 3 trials for post-bariatric hypoglycemia and congenital hyperinsulinism. Additionally, Amylyx is advancing AMX0035 for Wolfram syndrome and progressive supranuclear palsy, alongside early-stage candidates targeting amyotrophic lateral sclerosis (ALS).

The clinical-stage pharmaceutical sector is characterized by high research and development (R&D) costs and long regulatory lead times before reaching commercialization. Business models in this space rely heavily on intellectual property protection and the successful navigation of multi-phase clinical trials required for FDA approval. For a deeper look at these clinical milestones, investors may find ValueRays data useful.

Headlines to Watch Out For
  • Phase 3 clinical trial results for Avexitide determine future commercial viability
  • AMX0035 regulatory approval status for Wolfram syndrome and progressive supranuclear palsy
  • R&D expenditure levels impact cash runway and potential capital raises
  • Expansion into GLP-1 receptor antagonist market dictates long-term valuation growth
  • Clinical data readouts for AMX0114 influence investor confidence in ALS pipeline
Piotroski VR-10 (Strict) 0.0
Net Income: error (cannot be calculated; needs Net Income TTM and Revenue TTM)
FCF/TA: -0.41 > 0.02 and ΔFCF/TA 53.22 > 1.0
NWC/Revenue: error (cannot be calculated; needs Current Assets/Liabilities and Revenue current+prev)
CFO/TA -0.41 > 3% & CFO -120.4m > Net Income -150.1m
Net Debt/EBITDA: error (EBITDA <= 0)
Current Ratio: 17.85 > 1.5 & < 3
Outstanding Shares: last quarter (110.6m) vs 12m ago 29.02% < -2%
Gross Margin: error (current vs previous; cannot be calculated due to missing/invalid data or negative margin)
Asset Turnover: 0.0% > 50% (prev 39.77%; Δ -39.77% > 0%)
Interest Coverage Ratio: error (cannot be calculated; needs correct EBITDA TTM and Interest Expense TTM)
Altman Z'' -15.00
A: 0.92 (Total Current Assets 285.0m - Total Current Liabilities 16.0m) / Total Assets 293.6m
B: -2.70 (Retained Earnings -792.7m / Total Assets 293.6m)
C: -0.59 (EBIT TTM -150.8m / Avg Total Assets 256.6m)
D: -38.77 (Book Value of Equity -792.5m / Total Liabilities 20.4m)
Altman-Z'' = -47.44 = D
What is the price of AMLX shares?

As of May 30, 2026, the stock is trading at USD 14.35 with a total of 923,898 shares traded.
Over the past week, the price has changed by +3.02%, over one month by -8.01%, over three months by -5.41% and over the past year by +192.86%.

Is AMLX a buy, sell or hold?

Amylyx Pharmaceuticals has received a consensus analysts rating of 4.57. Therefore, it is recommended to buy AMLX.

  • StrongBuy: 5
  • Buy: 1
  • Hold: 1
  • Sell: 0
  • StrongSell: 0

What are the forecasts/targets for the AMLX price?
Analysts Target Price 23.4 63.1%
Amylyx Pharmaceuticals (AMLX) - Fundamental Data Overview as of 24 May 2026
Market Cap USD = 1.51b (1.51b USD * 1.0 USD.USD)
P/E Forward = 2.7739
P/S = 0.6625
P/B = 5.5265
Revenue TTM = 0.0 USD
EBIT TTM = -150.8m USD
EBITDA TTM = -150.3m USD
Long Term Debt = 4.48m USD (estimated: total debt 5.63m - short term 1.16m)
Short Term Debt = 1.16m USD (from shortTermDebt, last quarter)
Debt = 5.63m USD (from shortLongTermDebtTotal, last quarter) (leases 5.63m already included)
Net Debt = -274.1m USD (calculated: Debt 5.63m - CCE 279.8m)
Enterprise Value = 1.24b USD (1.51b + Debt 5.63m - CCE 279.8m)
 Interest Coverage Ratio = unknown (Ebit TTM -150.8m / Interest Expense TTM 0.0)
 EV/FCF = -10.25x (Enterprise Value 1.24b / FCF TTM -120.5m)
FCF Yield = -9.75% (FCF TTM -120.5m / Enterprise Value 1.24b)
 FCF Margin = unknown (Revenue TTM is 0 or missing)
 Net Margin = unknown
 Gross Margin = unknown ((Revenue TTM 0.0 - Cost of Revenue TTM 20.2m) / Revenue TTM)
 Tobins Q-Ratio = 4.21 (Enterprise Value 1.24b / Total Assets 293.6m)
Interest Expense / Debt = 0.0% (Interest Expense 0.0 / Debt 5.63m)
Taxrate = 21.0% (US default 21%)
NOPAT = -119.1m (EBIT -150.8m * (1 - 21.00%)) [loss with tax shield]
Current Ratio = 17.85 (Total Current Assets 285.0m / Total Current Liabilities 16.0m)
Debt / Equity = 0.02 (Debt 5.63m / totalStockholderEquity, last quarter 273.2m)
 Debt / EBITDA = 1.82 (negative EBITDA) (Net Debt -274.1m / EBITDA -150.3m)
 Debt / FCF = 2.27 (negative FCF - burning cash) (Net Debt -274.1m / FCF TTM -120.5m)
 Total Stockholder Equity = 269.6m (last 4 quarters mean from totalStockholderEquity)
RoA = -58.49% (Net Income -150.1m / Total Assets 293.6m)
RoE = -14.13% (Net Income TTM -150.1m / Total Stockholder Equity 1.06b)
RoCE = -14.13% (EBIT -150.8m / Capital Employed (Equity 1.06b + L.T.Debt 4.48m))
 RoIC = -42.72% (negative operating profit) (NOPAT -119.1m / Invested Capital 278.8m)
 WACC = 9.07% (E(1.51b)/V(1.52b) * Re(9.10%) + D(5.63m)/V(1.52b) * Rd(0.0%) * (1-Tc(0.21)))
Discount Rate = 9.10% (= CAPM, Blume Beta Adj.)
Shares (quarterly) Correlation: 74.00 | Cagr: 22.74%
 [DCF] Fair Price = unknown (Cash Flow -120.5m)
 EPS Correlation: N/A | EPS CAGR: N/A | SUE: -0.12 | # QB: 0
Revenue Correlation: N/A | Revenue CAGR: N/A | SUE: 0.0 | # QB: 0
EPS current Quarter (2026-06-30): EPS=-0.35 | Chg30d=+0.83% | Revisions=+0% | Analysts=8
EPS next Quarter (2026-09-30): EPS=-0.33 | Chg30d=+0.03% | Revisions=+0% | Analysts=8
EPS current Year (2026-12-31): EPS=-1.38 | Chg30d=-6.11% | Revisions=-9% | GrowthEPS=+9.5% | GrowthRev=+0.0%
EPS next Year (2027-12-31): EPS=-1.27 | Chg30d=-3.33% | Revisions=-9% | GrowthEPS=+8.6% | GrowthRev=+0.0%
[Analyst] Revisions Ratio: -9%