(DNLI) Denali Therapeutics - Ratings and Ratios

Exchange: NASDAQ • Country: United States • Currency: USD • Type: Common Stock • ISIN: US24823R1059

Alzheimer, Parkinson, ALS, Lysosomal Storage

DNLI EPS (Earnings per Share)

EPS (Earnings per Share) of DNLI over the last years for every Quarter: "2020-09": -0.54, "2020-12": 1.91, "2021-03": -0.58, "2021-06": -0.5, "2021-09": -0.69, "2021-12": -0.62, "2022-03": -0.53, "2022-06": -0.48, "2022-09": -0.84, "2022-12": -0.75, "2023-03": -0.8, "2023-06": 1.3, "2023-09": -0.72, "2023-12": -0.86, "2024-03": -0.78, "2024-06": -0.59, "2024-09": -0.63, "2024-12": -0.67, "2025-03": -0.78, "2025-06": -0.72, "2025-09": 0,

DNLI Revenue

Revenue of DNLI over the last years for every Quarter: 2020-09: 9.393, 2020-12: 316.815, 2021-03: 7.923, 2021-06: 22.939, 2021-09: 5.285, 2021-12: 12.514, 2022-03: 42.141, 2022-06: 52.48, 2022-09: 3.559, 2022-12: 10.283, 2023-03: 35.141, 2023-06: 294.123, 2023-09: 1.267, 2023-12: -305.043, 2024-03: 0, 2024-06: 0, 2024-09: 0, 2024-12: 0, 2025-03: 0, 2025-06: 0, 2025-09: null,

Description: DNLI Denali Therapeutics

Denali Therapeutics Inc (NASDAQ:DNLI) is a biotechnology company listed on the NASDAQ stock exchange, operating in the biotechnology sub-industry. The companys stock is classified as a common stock and is of US origin.

To assess the companys financial health, we can look at its market capitalization, which stands at approximately $1.955 billion. The absence of a price-to-earnings (P/E) ratio, both current and forward, suggests that the company is currently not profitable, which is not uncommon for companies in the biotechnology sector that are often in the development phase. The return on equity (RoE) is negative at -35.90%, indicating that the company is not generating profits from shareholders equity.

Key economic drivers for Denali Therapeutics include the success of its drug pipeline, particularly in the treatment of neurodegenerative diseases, and the ability to secure funding or partnerships to support its research and development activities. Key performance indicators (KPIs) to watch include the progress of its clinical trials, regulatory approvals, and the companys cash burn rate, which will be crucial in determining its ability to continue operations without additional capital infusion.

From a trading perspective, the stocks volatility, as indicated by its average true range (ATR) and beta, suggests that it is relatively sensitive to market movements, with a beta of 1.328 indicating that it is more volatile than the overall market. Investors should also monitor the companys cash position and funding requirements to assess the risk of dilution or financial distress.

The quarterly tax provision is an important aspect to analyze as it can provide insights into the companys financial performance and tax obligations. A thorough examination of this provision can reveal the companys effective tax rate, any tax loss carryforwards, and the impact of tax on its net income or loss.

DNLI Stock Overview

Market Cap in USD 2,255m
Sub-Industry Biotechnology
IPO / Inception 2017-12-08

DNLI Stock Ratings

Growth Rating -73.7%
Fundamental 26.3%
Dividend Rating -
Return 12m vs S&P 500 -47.4%
Analyst Rating 4.79 of 5

DNLI Dividends

Currently no dividends paid

DNLI Growth Ratios

Growth Correlation 3m 36.5%
Growth Correlation 12m -70.5%
Growth Correlation 5y -89.8%
CAGR 5y -16.35%
CAGR/Max DD 3y (Calmar Ratio) -0.25
CAGR/Mean DD 3y (Pain Ratio) -0.49
Sharpe Ratio 12m -0.58
Alpha -57.41
Beta 1.294
Volatility 55.58%
Current Volume 1365.8k
Average Volume 20d 2092.3k
Stop Loss 15.6 (-6.4%)
Signal -0.12

Piotroski VR‑10 (Strict, 0-10) 0.0

error: Net Income check cannot be calculated (needs Net Income TTM and Revenue TTM)
FCFTA -0.32 (>2.0%) and ΔFCFTA -4.79pp (YES ≥ +1.0pp, WARN ≥ +0.5pp)
error: NWC/Revenue cannot be calculated (needs Current Assets/Liabilities and Revenue current+prev)
CFO/TA -0.30 (>3.0%) and CFO -349.6m > Net Income -479.0m (YES >=105%, WARN >=100%)
NO Net Debt/EBITDA fails (EBITDA <= 0)
Current Ratio 10.27 (target 1.5–3.0; WARN 1.2–<1.5 or >3.0–5.0; CFO/TA gate active)
Outstanding Shares last Quarter (171.4m) change vs 12m ago 1.55% (target <= -2.0% for YES)
error: Gross Margin (current vs previous) cannot be calculated (needs Total Revenue and Cost Of Revenue)
Asset Turnover 0.0% (prev 22.00%; Δ -22.00pp) >=50% & Δ>=+2pp (WARN >=35% & Δ>=0)
Interest Coverage Ratio -11.94 (EBITDA TTM -511.6m / Interest Expense TTM -43.8m) >= 6 (WARN >= 3)

Altman Z'' -16.44

(A) 0.72 = (Total Current Assets 934.7m - Total Current Liabilities 91.1m) / Total Assets 1.17b
(B) -1.54 = Retained Earnings (Balance) -1.80b / Total Assets 1.17b
warn (B) unusual magnitude: -1.54 — check mapping/units
(C) -0.39 = EBIT TTM -522.7m / Avg Total Assets 1.33b
(D) -12.88 = Book Value of Equity -1.79b / Total Liabilities 139.2m
Total Rating: -16.44 = (6.56 * A) + (3.26 * B) + (6.72 * C) + (1.05 * D)

ValueRay F-Score (Strict, 0-100) 26.28

1. Piotroski 0.0pt = -5.0
2. FCF Yield -26.24% = -5.0
3. FCF Margin data missing
4. Debt/Equity 0.05 = 2.50
5. Debt/Ebitda 0.19 = 2.47
6. ROIC - WACC (= -55.99)% = -12.50
7. RoE -40.79% = -2.50
8. Rev. Trend -43.79% = -3.28
9. EPS Trend -8.23% = -0.41

What is the price of DNLI shares?

As of October 18, 2025, the stock is trading at USD 16.66 with a total of 1,365,791 shares traded.
Over the past week, the price has changed by +8.39%, over one month by +27.57%, over three months by +14.66% and over the past year by -39.24%.

Is Denali Therapeutics a good stock to buy?

No, based on ValueRay´s Fundamental Analyses, Denali Therapeutics (NASDAQ:DNLI) is currently (October 2025) a stock to sell. It has a ValueRay Fundamental Rating of 26.28 and therefor a negative outlook according to the companies health.
Based on momentum, paid dividends and discounted-cash-flow analyses, the fair value of DNLI is around 12.04 USD . This means that DNLI is currently overvalued and has a potential downside of -27.73%.

Is DNLI a buy, sell or hold?

Denali Therapeutics has received a consensus analysts rating of 4.79. Therefore, it is recommended to buy DNLI.
  • Strong Buy: 15
  • Buy: 4
  • Hold: 0
  • Sell: 0
  • Strong Sell: 0

What are the forecasts/targets for the DNLI price?

Issuer Target Up/Down from current
Wallstreet Target Price 31.6 89.7%
Analysts Target Price 31.6 89.7%
ValueRay Target Price 13.8 -17.2%

Last update: 2025-10-06 02:04

DNLI Fundamental Data Overview

Market Cap USD = 2.25b (2.25b USD * 1.0 USD.USD)
P/S = 3643.6484
P/B = 2.1639
Beta = 1.294
Revenue TTM = 0.0 USD
EBIT TTM = -522.7m USD
EBITDA TTM = -511.6m USD
Long Term Debt = 46.6m USD (from capitalLeaseObligations, last quarter)
Short Term Debt = 8.87m USD (from shortTermDebt, last quarter)
Debt = 46.6m USD (from shortLongTermDebtTotal, last quarter)
Net Debt = -94.6m USD (from netDebt column, last quarter)
Enterprise Value = 1.40b USD (2.25b + Debt 46.6m - CCE 899.0m)
Interest Coverage Ratio = -11.94 (Ebit TTM -522.7m / Interest Expense TTM -43.8m)
FCF Yield = -26.24% (FCF TTM -368.0m / Enterprise Value 1.40b)
FCF Margin = unknown (Revenue TTM is 0 or missing)
Net Margin = unknown
Gross Margin = unknown ((Revenue TTM 0.0 - Cost of Revenue TTM 3.04m) / Revenue TTM)
Tobins Q-Ratio = 1.20 (Enterprise Value 1.40b / Total Assets 1.17b)
Interest Expense / Debt = 45.28% (Interest Expense 21.1m / Debt 46.6m)
Taxrate = -0.02% (negative due to tax credits) (68.0k / -422.7m)
NOPAT = -522.8m (EBIT -522.7m * (1 - -0.02%)) [loss with tax shield] [negative tax rate / tax credits]
Current Ratio = 10.27 (Total Current Assets 934.7m / Total Current Liabilities 91.1m)
Debt / Equity = 0.05 (Debt 46.6m / totalStockholderEquity, last quarter 1.03b)
Debt / EBITDA = 0.19 (negative EBITDA) (Net Debt -94.6m / EBITDA -511.6m)
Debt / FCF = 0.26 (negative FCF - burning cash) (Net Debt -94.6m / FCF TTM -368.0m)
Total Stockholder Equity = 1.17b (last 4 quarters mean from totalStockholderEquity)
RoA = -41.08% (Net Income -479.0m / Total Assets 1.17b)
RoE = -40.79% (Net Income TTM -479.0m / Total Stockholder Equity 1.17b)
RoCE = -42.81% (EBIT -522.7m / Capital Employed (Equity 1.17b + L.T.Debt 46.6m))
RoIC = -44.51% (negative operating profit) (NOPAT -522.8m / Invested Capital 1.17b)
WACC = 11.48% (E(2.25b)/V(2.30b) * Re(10.78%) + D(46.6m)/V(2.30b) * Rd(45.28%) * (1-Tc(-0.00)))
Discount Rate = 10.78% (= CAPM, Blume Beta Adj.)
Shares Correlation 3-Years: 100.0 | Cagr: 11.36%
Fair Price DCF = unknown (Cash Flow -368.0m)
EPS Correlation: -8.23 | EPS CAGR: 80.68% | SUE: 4.0 | # QB: 1
Revenue Correlation: -43.79 | Revenue CAGR: -0.42% | SUE: -0.01 | # QB: 0

Additional Sources for DNLI Stock

News: Wall Street Journal | Benzinga | Yahoo Finance
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Fund Manager Positions: Dataroma | Stockcircle