(HOWL) Werewolf Therapeutics - Ratings and Ratios

Exchange: NASDAQ • Country: United States • Currency: USD • Type: Common Stock • ISIN: US95075A1079

Immunotherapy, Cytokines, Interleukins, Interferons

HOWL EPS (Earnings per Share)

EPS (Earnings per Share) of HOWL over the last years for every Quarter: "2020-09": null, "2020-12": null, "2021-03": -83.36, "2021-06": -3.82, "2021-09": -0.51, "2021-12": -0.66, "2022-03": -0.56, "2022-06": -0.53, "2022-09": -0.4, "2022-12": -0.39, "2023-03": -0.34, "2023-06": -0.14, "2023-09": -0.23, "2023-12": -0.33, "2024-03": -0.39, "2024-06": -0.43, "2024-09": -0.38, "2024-12": -0.46, "2025-03": -0.4, "2025-06": -0.4, "2025-09": 0,

HOWL Revenue

Revenue of HOWL over the last years for every Quarter: 2020-09: 0, 2020-12: 0, 2021-03: 0, 2021-06: 0, 2021-09: 0, 2021-12: 0, 2022-03: 0, 2022-06: 4.148, 2022-09: 4.97, 2022-12: 7.283, 2023-03: 4.464, 2023-06: 8.081, 2023-09: 5.897, 2023-12: 1.501, 2024-03: 0.742, 2024-06: 1.143, 2024-09: 0.049, 2024-12: -0.049, 2025-03: 0, 2025-06: 0, 2025-09: null,

Description: HOWL Werewolf Therapeutics

Werewolf Therapeutics, Inc. is a pioneering biopharmaceutical company that leverages its proprietary PREDATOR platform to develop conditionally activated molecules, designed to stimulate the bodys immune system to combat cancer. By harnessing the power of adaptive and innate immunity, the company aims to overcome the limitations of traditional proinflammatory immune therapies.

The companys pipeline is led by WTX-124 and WTX-330, two INDUKINE molecules that have entered clinical trials for the treatment of advanced or metastatic solid tumors and lymphoma. WTX-124, a conditionally activated Interleukin-2 molecule, is currently in Phase I/Ib trials, while WTX-330, a conditionally activated Interleukin-12 molecule, is in Phase I trials. These candidates have the potential to revolutionize the treatment of various cancers.

Beyond its lead candidates, Werewolf Therapeutics is developing a range of other promising therapeutics, including JZP898, a conditionally activated interferon alpha INDUKINE molecule, WTX-921, a conditionally activated IL-10 INDUKINE molecule, and WTX-712 and WTX-518, INDUKINE molecules targeting Interleukin-21 and Interleukin-18, respectively. These molecules are being developed for the treatment of various cancers and inflammatory diseases, including inflammatory bowel disease.

Analyzing the , we observe that the stock has broken above its 20-day and 50-day Simple Moving Averages (SMA), indicating a potential bullish trend. However, the stock remains below its 200-day SMA, suggesting that the long-term trend is still bearish. The Average True Range (ATR) indicates a relatively high volatility, which may be attributed to the companys clinical trial updates and the inherent risks associated with biopharmaceutical development. With the current price at $1.14 and an ATR of $0.10 (8.83% of the current price), we can expect significant price movements in the short term.

Considering the , Werewolf Therapeutics has a market capitalization of $44.87M USD, with no reported earnings and a negative Return on Equity (RoE) of -75.35%. This is expected for a company in the biopharmaceutical industry that is still in the development stage. As the company progresses its pipeline, particularly with the ongoing clinical trials for WTX-124 and WTX-330, we can anticipate potential catalysts that may drive the stock price.

Forecasting the stocks performance based on both and , we anticipate a potential short-term rally, driven by the stocks recent breakout above its short-term SMAs and potential positive updates from the ongoing clinical trials. However, the long-term trend remains uncertain, and the stocks performance will be heavily influenced by the companys ability to progress its pipeline and achieve significant milestones. A potential price target could be around $2.00, representing a 75% increase from the current price, assuming successful trial outcomes and continued progress in the companys development pipeline.

HOWL Stock Overview

Market Cap in USD 88m
Sub-Industry Biotechnology
IPO / Inception 2021-04-30

HOWL Stock Ratings

Growth Rating -59.2%
Fundamental 27.6%
Dividend Rating -
Return 12m vs S&P 500 -24.6%
Analyst Rating 4.67 of 5

HOWL Dividends

Currently no dividends paid

HOWL Growth Ratios

Growth Correlation 3m 75.7%
Growth Correlation 12m -33%
Growth Correlation 5y -82.2%
CAGR 5y -22.95%
CAGR/Max DD 3y (Calmar Ratio) -0.25
CAGR/Mean DD 3y (Pain Ratio) -0.43
Sharpe Ratio 12m -1.86
Alpha -25.36
Beta 0.766
Volatility 95.40%
Current Volume 775.5k
Average Volume 20d 1099.9k
Stop Loss 1.6 (-9.1%)
Signal 0.36

Piotroski VR‑10 (Strict, 0-10) 0.0

Net Income (-73.1m TTM) > 0 and > 6% of Revenue (6% = 113.1k TTM)
FCFTA -0.66 (>2.0%) and ΔFCFTA -38.64pp (YES ≥ +1.0pp, WARN ≥ +0.5pp)
NWC/Revenue 3462 % (prev 1372 %; Δ 2091 pp) (YES ≤20% & Δ≤-1pp; WARN ≤25% & Δ≤0 oder ≤40% & Δ≤-3pp)
CFO/TA -0.66 (>3.0%) and CFO -60.8m > Net Income -73.1m (YES >=105%, WARN >=100%)
NO Net Debt/EBITDA fails (EBITDA <= 0)
Current Ratio 5.30 (target 1.5–3.0; WARN 1.2–<1.5 or >3.0–5.0; CFO/TA gate active)
Outstanding Shares last Quarter (45.0m) change vs 12m ago 3.36% (target <= -2.0% for YES)
Gross Margin 8.33% (prev 80.36%; Δ -72.03pp) >=18% & Δ>=+0.5pp (WARN >=15% & Δ>=0)
Asset Turnover 1.53% (prev 6.04%; Δ -4.51pp) >=50% & Δ>=+2pp (WARN >=35% & Δ>=0)
Interest Coverage Ratio -13.41 (EBITDA TTM -66.3m / Interest Expense TTM 5.08m) >= 6 (WARN >= 3)

Altman Z'' -24.22

(A) 0.71 = (Total Current Assets 80.4m - Total Current Liabilities 15.2m) / Total Assets 92.6m
(B) -4.87 = Retained Earnings (Balance) -450.7m / Total Assets 92.6m
warn (B) unusual magnitude: -4.87 — check mapping/units
(C) -0.55 = EBIT TTM -68.1m / Avg Total Assets 123.1m
(D) -8.82 = Book Value of Equity -450.7m / Total Liabilities 51.1m
Total Rating: -24.22 = (6.56 * A) + (3.26 * B) + (6.72 * C) + (1.05 * D)

ValueRay F-Score (Strict, 0-100) 27.62

1. Piotroski 0.0pt = -5.0
2. FCF Yield data missing
3. FCF Margin data missing
4. Debt/Equity 0.24 = 2.47
5. Debt/Ebitda 1.03 = 1.72
6. ROIC - WACC (= -67.60)% = -12.50
7. RoE -111.9% = -2.50
8. Rev. Trend -91.95% = -6.90
9. EPS Trend 6.40% = 0.32

What is the price of HOWL shares?

As of October 16, 2025, the stock is trading at USD 1.76 with a total of 775,491 shares traded.
Over the past week, the price has changed by -6.38%, over one month by +23.08%, over three months by +34.35% and over the past year by -12.44%.

Is Werewolf Therapeutics a good stock to buy?

No, based on ValueRay´s Fundamental Analyses, Werewolf Therapeutics (NASDAQ:HOWL) is currently (October 2025) a stock to sell. It has a ValueRay Fundamental Rating of 27.62 and therefor a negative outlook according to the companies health.
Based on momentum, paid dividends and discounted-cash-flow analyses, the fair value of HOWL is around 1.51 USD . This means that HOWL is currently overvalued and has a potential downside of -14.2%.

Is HOWL a buy, sell or hold?

Werewolf Therapeutics has received a consensus analysts rating of 4.67. Therefore, it is recommended to buy HOWL.
  • Strong Buy: 4
  • Buy: 2
  • Hold: 0
  • Sell: 0
  • Strong Sell: 0

What are the forecasts/targets for the HOWL price?

Issuer Target Up/Down from current
Wallstreet Target Price 6.8 288.1%
Analysts Target Price 6.8 288.1%
ValueRay Target Price 1.7 -4%

Last update: 2025-10-03 13:17

HOWL Fundamental Data Overview

Market Cap USD = 87.8m (87.8m USD * 1.0 USD.USD)
P/S = 52.2151
P/B = 2.1175
Beta = 0.766
Revenue TTM = 1.89m USD
EBIT TTM = -68.1m USD
EBITDA TTM = -66.3m USD
Long Term Debt = 24.7m USD (from longTermDebt, last quarter)
Short Term Debt = 2.91m USD (from shortTermDebt, last quarter)
Debt = 10.0m USD (from shortLongTermDebtTotal, last quarter)
Net Debt = -68.5m USD (from netDebt column, last quarter)
Enterprise Value = 19.3m USD (87.8m + Debt 10.0m - CCE 78.5m)
Interest Coverage Ratio = -13.41 (Ebit TTM -68.1m / Interest Expense TTM 5.08m)
FCF Yield = -315.0% (FCF TTM -61.0m / Enterprise Value 19.3m)
FCF Margin = -3234 % (FCF TTM -61.0m / Revenue TTM 1.89m)
Net Margin = -3880 % (Net Income TTM -73.1m / Revenue TTM 1.89m)
Gross Margin = 8.33% ((Revenue TTM 1.89m - Cost of Revenue TTM 1.73m) / Revenue TTM)
Gross Margin QoQ = none% (prev none%)
Tobins Q-Ratio = 0.21 (Enterprise Value 19.3m / Total Assets 92.6m)
Interest Expense / Debt = 12.96% (Interest Expense 1.30m / Debt 10.0m)
Taxrate = 21.0% (US default 21%)
NOPAT = -53.8m (EBIT -68.1m * (1 - 21.00%)) [loss with tax shield]
Current Ratio = 5.30 (Total Current Assets 80.4m / Total Current Liabilities 15.2m)
Debt / Equity = 0.24 (Debt 10.0m / totalStockholderEquity, last quarter 41.5m)
Debt / EBITDA = 1.03 (negative EBITDA) (Net Debt -68.5m / EBITDA -66.3m)
Debt / FCF = 1.12 (negative FCF - burning cash) (Net Debt -68.5m / FCF TTM -61.0m)
Total Stockholder Equity = 65.4m (last 4 quarters mean from totalStockholderEquity)
RoA = -79.02% (Net Income -73.1m / Total Assets 92.6m)
RoE = -111.9% (Net Income TTM -73.1m / Total Stockholder Equity 65.4m)
RoCE = -75.56% (EBIT -68.1m / Capital Employed (Equity 65.4m + L.T.Debt 24.7m))
RoIC = -58.62% (negative operating profit) (NOPAT -53.8m / Invested Capital 91.7m)
WACC = 8.98% (E(87.8m)/V(97.8m) * Re(8.84%) + D(10.0m)/V(97.8m) * Rd(12.96%) * (1-Tc(0.21)))
Discount Rate = 8.84% (= CAPM, Blume Beta Adj.)
Shares Correlation 3-Years: 100.0 | Cagr: 10.91%
Fair Price DCF = unknown (Cash Flow -61.0m)
EPS Correlation: 6.40 | EPS CAGR: 74.11% | SUE: 4.0 | # QB: 1
Revenue Correlation: -91.95 | Revenue CAGR: -70.40% | SUE: 0.0 | # QB: 0

Additional Sources for HOWL Stock

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