XENE Stock Analysis: Xenon Pharmaceuticals | NASDAQ

Biotechnology | NASDAQ, USA | Market Cap: 5.893m USD | 12M Return: 99.1% | Charts, Fundamentals & Technical Analysis

Azetukalner, Epilepsy, Pain, Sodium Channel
Total Rating 44
Safety 87
Buy Signal 0.52
Biotechnology
Industry Rotation: +30.9
Market Cap: 5.89B
Avg Turnover: 81.0M
Risk 3d forecast
Volatility38.3%
VaR 5th Pctl6.16%
VaR vs Median-2.38%
Reward TTM
Sharpe Ratio1.33
Rel. Str. IBD88.5
Rel. Str. Peer Group51.7
Character TTM
Beta0.145
Beta Downside0.180
Hurst Exponent0.435
Drawdowns 3y
Max DD43.59%
CAGR/Max DD0.39
CAGR/Mean DD0.97
EPS (Earnings per Share) EPS (Earnings per Share) of XENE over the last years for every Quarter: "2021-06": -0.51, "2021-09": -0.36, "2021-12": -0.48, "2022-03": -0.35, "2022-06": -0.55, "2022-09": -0.57, "2022-12": -0.57, "2023-03": -0.63, "2023-06": -0.72, "2023-09": -0.73, "2023-12": -0.64, "2024-03": -0.62, "2024-06": -0.75, "2024-09": -0.81, "2024-12": -0.84, "2025-03": -0.83, "2025-06": -1.07, "2025-09": -1.15, "2025-12": -1.31, "2026-03": -1.17,
Last SUE: 0.49
Qual. Beats: 0
Revenue Revenue of XENE over the last years for every Quarter: 2021-06: 2.218, 2021-09: 8.124, 2021-12: 3.737, 2022-03: 8.766, 2022-06: 0.536, 2022-09: 0.132, 2022-12: 0.008766, 2023-03: 0, 2023-06: 0, 2023-09: 0, 2023-12: 5.38, 2024-03: 0, 2024-06: 0, 2024-09: 0, 2024-12: 2.516, 2025-03: 7.5, 2025-06: 0, 2025-09: 0, 2025-12: 0, 2026-03: 0,
Last SUE: -0.50
Qual. Beats: 0

Warnings

No concerns identified

Tailwinds

Tailwind

Seasonality 10.5 years of data

Jan +0.7% 0
Feb +0.9% 26
Mar -5.2% 30
Apr +1.7% 11
May -4.5% 34
Jun +0.0% 5
Jul -1.1% 30
Aug +5.2% 36
Sep -9.3% 56
Oct +1.5% 12
Nov +3.4% 9
Dec +8.2% 22

How good or bad each month usually is (without trend). The score below shows how much you can trust it: 0 = pure chance, >40 gets interesting and >55 is strong.

Description: XENE Xenon Pharmaceuticals

Xenon Pharmaceuticals Inc. (NASDAQ: XENE) is a clinical-stage, neuroscience-focused biopharmaceutical company headquartered in Burnaby, Canada, that develops therapeutics for neurological and psychiatric disorders. Founded in 1996 and listed on NASDAQ since 2014, the company operates as a small-cap biotech within the Health Care sector, relying on equity capital and partnerships to fund its drug development pipeline.

The companys lead candidate, Azetukalner, is a Kv7 potassium channel opener currently in Phase 3 clinical trials for epilepsy (focal onset seizures and primary generalized tonic-clonic seizures) and is also being evaluated in neuropsychiatric indications including major depressive disorder and bipolar depression. Earlier-stage assets include XEN1701 (sodium channel) and XEN1120 (Kv7 potassium channel), both in Phase 1 for pain.

Xenon supplements its internal pipeline through a license and collaboration agreement with Neurocrine Biosciences for NBI-921355, a Nav1.2/1.6 sodium channel inhibitor in Phase 1 development for certain forms of epilepsy - a partnership structure commonly used by clinical-stage biotechs to share development costs and expand pipeline reach.

Headlines to Watch Out For
  • Azetukalner Phase 3 epilepsy data readout approaches
  • Neurocrine collaboration delivers milestone revenue and validation
  • Cash burn and runway concerns grow as clinical spending accelerates
Piotroski VR-10 (Strict) 0.0
Net Income: -383.2m TTM > 0 and > 6% of Revenue
FCF/TA: -0.22 > 0.02 and ΔFCF/TA 4.93 > 1.0
NWC/Revenue: 14.2k% < 20% (prev 5.33k%; Δ 8.90k% < -1%)
CFO/TA -0.22 > 3% & CFO -306.4m > Net Income -383.2m
Net Debt/EBITDA: error (EBITDA <= 0)
Current Ratio: 27.79 > 1.5 & < 3
Outstanding Shares: last quarter (87.3m) vs 12m ago 11.00% < -2%
Gross Margin: error (current vs previous; cannot be calculated due to missing/invalid data or negative margin)
Asset Turnover: 0.70% > 50% (prev 1.35%; Δ -0.64% > 0%)
Interest Coverage Ratio: error (cannot be calculated; needs correct EBIT TTM and Interest Expense TTM)
Altman Z'' 10.00
A: 0.77 (Total Current Assets 1.11b - Total Current Liabilities 39.8m) / Total Assets 1.39b
B: -0.97 (Retained Earnings -1.35b / Total Assets 1.39b)
C: -0.38 (EBIT TTM -401.5m / Avg Total Assets 1.07b)
D: 27.31 (Book Value of Equity 1.34b / Total Liabilities 49.0m)
Altman-Z'' = 28.02 = AAA
Beneish M -3.95
DSRI: 0.18 (Receivables 1.17m/8.65m, Revenue 7.50m/10.0m)
GMI: 1.00 (fallback, negative margins)
AQI: 0.89 (AQ_t 0.19 / AQ_t-1 0.22)
SGI: 0.75 (Revenue 7.50m / 10.0m)
TATA: -0.06 (NI -383.2m - CFO -306.4m) / TA 1.39b)
Beneish M = -3.95 (Cap -4..+1) = AAA
What is the price of XENE shares?

As of July 08, 2026, the stock is trading at USD 63.37 with a total of 1,420,614 shares traded. Over the past week, the price has changed by +5.39%, over one month by +23.75%, over three months by +9.92% and over the past year by +99.09%.

Current recommended Stop Loss: 61.20 (which is 3.4% or 1.2 ATR below the current price).

Is XENE a buy, sell or hold?

Xenon Pharmaceuticals has received a consensus analysts rating of 4.74. Therefore, it is recommended to buy XENE.

  • StrongBuy: 14
  • Buy: 5
  • Hold: 0
  • Sell: 0
  • StrongSell: 0

What are the forecasts/targets for the XENE price?
Analysts Target Price 80.6 27.1%
Xenon Pharmaceuticals (XENE) - Fundamental Data Overview as of 05 July 2026
Market Cap USD = 5.89b (5.89b USD * 1.0 USD.USD)
P/S = 727.4404
P/B = 4.357
P/EG = -0.06
Revenue TTM = 7.50m USD
EBIT TTM = -401.5m USD
EBITDA TTM = -399.0m USD
Long Term Debt = 5.93m USD (estimated: total debt 7.49m - short term 1.56m)
Short Term Debt = 1.56m USD (from shortTermDebt, last quarter)
Debt = 7.49m USD (from shortLongTermDebtTotal, last quarter) (leases 7.49m already included)
Net Debt = -1.09b USD (calculated: Debt 7.49m - CCE 1.09b)
Enterprise Value = 4.81b USD (5.89b + Debt 7.49m - CCE 1.09b)
 Interest Coverage Ratio = unknown (Ebit TTM -401.5m / Interest Expense TTM 0.0)
 EV/FCF = -15.64x (Enterprise Value 4.81b / FCF TTM -307.3m)
FCF Yield = -6.39% (FCF TTM -307.3m / Enterprise Value 4.81b)
 FCF Margin = -4.10k% (FCF TTM -307.3m / Revenue TTM 7.50m)
 Net Margin = -5.11k% (Net Income TTM -383.2m / Revenue TTM 7.50m)
 Gross Margin = unknown ((Revenue TTM 7.50m - Cost of Revenue TTM 78.9m) / Revenue TTM)
 Tobins Q-Ratio = 3.47 (Enterprise Value 4.81b / Total Assets 1.39b)
Interest Expense / Debt = 0.0% (Interest Expense 0.0 / Debt 7.49m)
Taxrate = 21.0% (US federal default 21%)
NOPAT = -317.2m (EBIT -401.5m * (1 - 21.00%)) [loss with tax shield]
Current Ratio = 27.79 (Total Current Assets 1.11b / Total Current Liabilities 39.8m)
Debt / Equity = 0.01 (Debt 7.49m / totalStockholderEquity, last quarter 1.34b)
 Debt / EBITDA = 2.72 (negative EBITDA) (Net Debt -1.09b / EBITDA -399.0m)
 Debt / FCF = 3.54 (negative FCF - burning cash) (Net Debt -1.09b / FCF TTM -307.3m)
 Total Stockholder Equity = 778.3m (last 4 quarters mean from totalStockholderEquity)
RoA = -35.98% (Net Income -383.2m / Total Assets 1.39b)
RoE = -49.23% (Net Income TTM -383.2m / Total Stockholder Equity 778.3m)
RoCE = -51.20% (EBIT -401.5m / Capital Employed (Equity 778.3m + L.T.Debt 5.93m))
 RoIC = -23.53% (negative operating profit) (NOPAT -317.2m / Invested Capital 1.35b)
 WACC = 6.48% (E(5.89b)/V(5.90b) * Re(6.49%) + D(7.49m)/V(5.90b) * Rd(0.0%) * (1-Tc(0.21)))
Discount Rate = 6.49% (= CAPM, Blume Beta Adj.)
Shares (quarterly) Correlation: 85.63 | Cagr: 12.31%
 [DCF] Fair Price = unknown (Cash Flow -307.3m)
 EPS Correlation: N/A | EPS CAGR: N/A | SUE: 0.49 | # QB: 0
Revenue Correlation: N/A | Revenue CAGR: N/A | SUE: -0.50 | # QB: 0
EPS current Quarter (2026-06-30): EPS=-1.16 | Chg30d=+1.34% | Revisions=+21% | Analysts=14
EPS next Quarter (2026-09-30): EPS=-1.19 | Chg30d=+0.86% | Revisions=+36% | Analysts=14
EPS current Year (2026-12-31): EPS=-4.81 | Chg30d=+0.34% | Revisions=-6% | GrowthEPS=-10.3% | GrowthRev=-72.5%
EPS next Year (2027-12-31): EPS=-5.01 | Chg30d=-5.88% | Revisions=-31% | GrowthEPS=-4.1% | GrowthRev=+1602.7%
[Analyst] Revisions Ratio: +4% (up=25, down=23)